Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression

Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression

Proprotein convertase subtilisin-kexin-9 (PCSK9) inhibition markedly augments the LDL lowering action of statins. The combination is being evaluated for long-term effects on atherosclerotic disease outcomes. However, effects of combined treatment on hepatic cholesterol and bile acid metabolism have...

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Bibliographic Details
Main Authors: Rex A. Parker, Ricardo Garcia, Carol S. Ryan, Xiaoqin Liu, Petia Shipkova, Valentin Livanov, Pritesh Patel, Siew P. Ho
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Journal of Lipid Research
Subjects:
proprotein convertase subtilisin-kexin-9 inhibitors
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
statins
CYP7A1
bile acid transporter
cholestasis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351300

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http://www.sciencedirect.com/science/article/pii/S0022227520351300

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