USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

Though ubiquitin is known to broadly influence endosomal trafficking, few ubiquitin-utilizing enzymes targeting endosomal regulators are known. Here, the authors find that the deubiquitylating enzyme (DUB) USP32 influences endosomal membrane dynamics by deubiquitinating Rab7.

Bibliographic Details
Main Authors: Aysegul Sapmaz, Ilana Berlin, Erik Bos, Ruud H. Wijdeven, Hans Janssen, Rebecca Konietzny, Jimmy J. Akkermans, Ayse E. Erson-Bensan, Roman I. Koning, Benedikt M. Kessler, Jacques Neefjes, Huib Ovaa
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09437-x

Internet

https://doi.org/10.1038/s41467-019-09437-x

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