Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Summary: Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, chromatin, and/or signaling regulators. The t(8;21) translocation generates the aberrant transcription factor RUNX1-ETO (RUNX1-RUNX1T1), which by itself is insufficien...

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Bibliographic Details
Main Authors: Monica Nafria, Peter Keane, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Constanze Bonifer
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
Acute Myeloid Leukemia (AML)
RUNX1-ETO
chromatin
human ES cell differentiation
myelopoiesis
single cell RNA-Seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306446

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http://www.sciencedirect.com/science/article/pii/S2211124720306446

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