A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer

A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer

Mutated cancer antigens, or neoantigens, represent compelling immunological targets and appear to underlie the success of several forms of immunotherapy. While there are anecdotal reports of neoantigen-specific T cells being present in the peripheral blood and/or tumors of cancer patients, effective...

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Bibliographic Details
Main Authors: Spencer D. Martin, Darin A. Wick, Julie S. Nielsen, Nicole Little, Robert A. Holt, Brad H. Nelson
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
neoantigen
immunotherapy
adoptive t cell therapy
mutations
t cells
mini-line
ovarian cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1371895

Internet

http://dx.doi.org/10.1080/2162402X.2017.1371895

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