Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc+ Monocytes in Rectal Cancer

Neoadjuvant Radiochemotherapy Significantly Alters the Phenotype of Plasmacytoid Dendritic Cells and 6-Sulfo LacNAc+ Monocytes in Rectal Cancer

Neoadjuvant radiochemotherapy (nRCT) can significantly influence the tumor immune architecture that plays a pivotal role in regulating tumor growth. Whereas, various studies have investigated the effect of nRCT on tumor-infiltrating T cells, little is known about its impact on the frequency and acti...

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Bibliographic Details
Main Authors: Felix Wagner, Ulrike Hölig, Friederike Wilczkowski, Ioana Plesca, Ulrich Sommer, Rebekka Wehner, Maximilian Kießler, Armin Jarosch, Katharina Flecke, Maia Arsova, Antje Tunger, Andreas Bogner, Christoph Reißfelder, Jürgen Weitz, Knut Schäkel, Esther G. C. Troost, Mechthild Krause, Gunnar Folprecht, Martin Bornhäuser, Michael P. Bachmann, Daniela Aust, Gustavo Baretton, Marc Schmitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
plasmacytoid dendritic cells
6-sulfo LacNAc+ monocytes
CD8+ T cells
tumor immune architecture
radiochemotherapy
rectal cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00602/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00602/full

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