Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here, we explored the impact of an FA-supplemented diet (5× FASD, containing five-fold higher FA than recommen...

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Bibliographic Details
Main Authors: Marta Cosín-Tomás, Yan Luan, Daniel Leclerc, Olga V. Malysheva, Nidia Lauzon, Renata H. Bahous, Karen E. Christensen, Marie A. Caudill, Rima Rozen
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Nutrients
Subjects:
choline
folate
MTHFR
neurodevelopment
phospholipids
Online Access:https://www.mdpi.com/2072-6643/12/6/1716

Internet

https://www.mdpi.com/2072-6643/12/6/1716

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