Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.

Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism. Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells. Here we investigated the regulation of Angptl4 and its role i...

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Bibliographic Details
Main Authors: Marius R Robciuc, Paulina Skrobuk, Andrey Anisimov, Vesa M Olkkonen, Kari Alitalo, Robert H Eckel, Heikki A Koistinen, Matti Jauhiainen, Christian Ehnholm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3464237?pdf=render