The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)

The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)

Carbon monoxide (CO) produced by heme oxygenase (HO)-1 and HO-2 or released from the CO-donor, tricarbonyldichlororuthenium (II) dimer (CORM-2) causes vasodilation, with unknown efficacy against stress-induced gastric lesions. We studied whether pretreatment with CORM-2 (0.1–10 mg/kg oral gavage (i....

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Bibliographic Details
Main Authors: Katarzyna Magierowska, Marcin Magierowski, Marcin Surmiak, Juliusz Adamski, Agnieszka Irena Mazur-Bialy, Robert Pajdo, Zbigniew Sliwowski, Slawomir Kwiecien, Tomasz Brzozowski
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
carbon monoxide
stress
nitric oxide
gastroprotection
gastric blood flow
heme oxygenase-1
cyclooxygenases
soluble guanylyl cyclase
hypoxia inducible factor 1α
Online Access:http://www.mdpi.com/1422-0067/17/4/442

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http://www.mdpi.com/1422-0067/17/4/442

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