Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson’s disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates, and that size and topological structural properties are crucial factors fo...

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Bibliographic Details
Main Authors: Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson disease
α-synuclein oligomers
neurodegeneration
neuroinflammation
microglia
motor deficits
Online Access:https://www.mdpi.com/1422-0067/21/22/8535

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https://www.mdpi.com/1422-0067/21/22/8535

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