Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Nicotinic acetylcholine receptors (nAChRs) are found throughout the mammalian body and have been studied extensively because of their implication in a myriad of diseases. &#945;-Conotoxins (&#945;-CTxs) are peptide neurotoxins found in the venom of marine snails of genus <i>Conus</i...

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Bibliographic Details
Main Authors: Matthew W. Turner, Leanna A. Marquart, Paul D. Phillips, Owen M. McDougal
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Toxins
Subjects:
α-conotoxins (α-CTxs)
nicotinic acetylcholine receptors (nAChRs)
mutational analysis
positional scanning synthetic combinatorial libraries (PS-SCL)
acetylcholine binding protein (AChBP)
protein surface topography (PST)
genetic algorithm managed peptide mutant screening (GAMPMS)
molecular dynamics (MD)
solid phase peptide synthesis (SPPS)
Online Access:https://www.mdpi.com/2072-6651/11/2/113

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https://www.mdpi.com/2072-6651/11/2/113

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