Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Nicotinic acetylcholine receptors (nAChRs) are found throughout the mammalian body and have been studied extensively because of their implication in a myriad of diseases. α-Conotoxins (α-CTxs) are peptide neurotoxins found in the venom of marine snails of genus <i>Conus</i...

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Bibliographic Details
Main Authors:	Matthew W. Turner, Leanna A. Marquart, Paul D. Phillips, Owen M. McDougal
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Series:	Toxins
Subjects:	α-conotoxins (α-CTxs) nicotinic acetylcholine receptors (nAChRs) mutational analysis positional scanning synthetic combinatorial libraries (PS-SCL) acetylcholine binding protein (AChBP) protein surface topography (PST) genetic algorithm managed peptide mutant screening (GAMPMS) molecular dynamics (MD) solid phase peptide synthesis (SPPS)
Online Access:	https://www.mdpi.com/2072-6651/11/2/113

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