Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining

Summary: DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-mediated end-joining (MMEJ). Here, we investigate Polθ...

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Bibliographic Details
Main Authors: Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L. Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T. Pomerantz
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001340

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http://www.sciencedirect.com/science/article/pii/S2211124721001340

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