Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining
Summary: DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-mediated end-joining (MMEJ). Here, we investigate Polθ...
Main Authors: | Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L. Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T. Pomerantz |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721001340 |
Similar Items
-
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
by: Samuel J. Black, et al.
Published: (2019-09-01) -
Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
by: Samuel J. Black, et al.
Published: (2020-04-01) -
DNA Polymerase θ: A Unique Multifunctional End-Joining Machine
by: Samuel J. Black, et al.
Published: (2016-09-01) -
Microhomology Selection for Microhomology Mediated End Joining in <i>Saccharomyces cerevisiae</i>
by: Kihoon Lee, et al.
Published: (2019-04-01) -
How RNA transcripts coordinate DNA recombination and repair
by: Shane McDevitt, et al.
Published: (2018-03-01)