Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations

Breast feeding results in long term health benefits in the prevention of communicable and non-communicable diseases at both individual and population levels. Geographical location directly impacts the composition of breast milk including microbiota and lipids. The aim of this study was to investigat...

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Main Authors: Himanshu Kumar, Elloise du Toit, Amruta Kulkarni, Juhani Aakko, Kaisa Linderborg, Yumei Zhang, Mark Nicol, Erika Isolauri, Baoru Yang, MARIA CARMEN COLLADO, Seppo Salminen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01619/full
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spelling doaj-032c540e18ee48b5a937cdeddbbfd1db2020-11-24T21:17:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-10-01710.3389/fmicb.2016.01619217349Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locationsHimanshu Kumar0Elloise du Toit1Amruta Kulkarni2Juhani Aakko3Juhani Aakko4Kaisa Linderborg5Yumei Zhang6Mark Nicol7Mark Nicol8Erika Isolauri9Baoru Yang10MARIA CARMEN COLLADO11MARIA CARMEN COLLADO12Seppo Salminen13University of TurkuUniversity of Cape TownUniversity of TurkuUniversity of TurkuUniversity of TurkuUniversity of TurkuPeking UniversityUniversity of Cape TownGroote Schuur HospitalUniversity of TurkuUniversity of TurkuUniversity of TurkuNational Research Council (IATA-CSIC)University of TurkuBreast feeding results in long term health benefits in the prevention of communicable and non-communicable diseases at both individual and population levels. Geographical location directly impacts the composition of breast milk including microbiota and lipids. The aim of this study was to investigate the influence of geographical location, i.e., Europe (Spain and Finland), Africa (South Africa) and Asia (China), on breast milk microbiota and lipid composition in samples obtained from healthy mothers after the first month of lactation. Altogether, 80 women (20 from each country) participated in the study, with equal number of women who delivered by vaginal or caesarean section from each country. Lipid composition particularly that of polyunsaturated fatty acids differed between the countries, with the highest amount of n-6 PUFA (25.6%) observed in the milk of Chinese women. Milk microbiota composition also differed significantly between the countries (p=0.002). Among vaginally delivered women, Spanish women had highest amount of Bacteroidetes whereas Chinese women had highest amount of Actinobacteria. Women who had had a caesarean section had higher amount of Proteobacteria as observed in the milk of the Spanish and South African women. Interestingly, the Spanish and South African women had significantly higher bacterial genes mapped to lipid, amino acid and carbohydrate metabolism (p<0.05). Association of the lipid profile with the microbiota revealed that monounsaturated fatty acids were negatively associated with Proteobacteria (r= -0.43, p<0.05), while Lactobacillus genus was associated with monounsaturated fatty acids (r= -0.23, p=0.04). These findings reveal that the milk microbiota and lipid composition exhibit differences based on geographical locations in addition to the differences observed due to the mode of delivery.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01619/fullFatty AcidsGeographymicrobiomedeliveryhuman milk
collection DOAJ
language English
format Article
sources DOAJ
author Himanshu Kumar
Elloise du Toit
Amruta Kulkarni
Juhani Aakko
Juhani Aakko
Kaisa Linderborg
Yumei Zhang
Mark Nicol
Mark Nicol
Erika Isolauri
Baoru Yang
MARIA CARMEN COLLADO
MARIA CARMEN COLLADO
Seppo Salminen
spellingShingle Himanshu Kumar
Elloise du Toit
Amruta Kulkarni
Juhani Aakko
Juhani Aakko
Kaisa Linderborg
Yumei Zhang
Mark Nicol
Mark Nicol
Erika Isolauri
Baoru Yang
MARIA CARMEN COLLADO
MARIA CARMEN COLLADO
Seppo Salminen
Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
Frontiers in Microbiology
Fatty Acids
Geography
microbiome
delivery
human milk
author_facet Himanshu Kumar
Elloise du Toit
Amruta Kulkarni
Juhani Aakko
Juhani Aakko
Kaisa Linderborg
Yumei Zhang
Mark Nicol
Mark Nicol
Erika Isolauri
Baoru Yang
MARIA CARMEN COLLADO
MARIA CARMEN COLLADO
Seppo Salminen
author_sort Himanshu Kumar
title Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
title_short Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
title_full Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
title_fullStr Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
title_full_unstemmed Distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
title_sort distinct patterns in human milk microbiota and fatty acid profiles across specific geographic locations
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2016-10-01
description Breast feeding results in long term health benefits in the prevention of communicable and non-communicable diseases at both individual and population levels. Geographical location directly impacts the composition of breast milk including microbiota and lipids. The aim of this study was to investigate the influence of geographical location, i.e., Europe (Spain and Finland), Africa (South Africa) and Asia (China), on breast milk microbiota and lipid composition in samples obtained from healthy mothers after the first month of lactation. Altogether, 80 women (20 from each country) participated in the study, with equal number of women who delivered by vaginal or caesarean section from each country. Lipid composition particularly that of polyunsaturated fatty acids differed between the countries, with the highest amount of n-6 PUFA (25.6%) observed in the milk of Chinese women. Milk microbiota composition also differed significantly between the countries (p=0.002). Among vaginally delivered women, Spanish women had highest amount of Bacteroidetes whereas Chinese women had highest amount of Actinobacteria. Women who had had a caesarean section had higher amount of Proteobacteria as observed in the milk of the Spanish and South African women. Interestingly, the Spanish and South African women had significantly higher bacterial genes mapped to lipid, amino acid and carbohydrate metabolism (p<0.05). Association of the lipid profile with the microbiota revealed that monounsaturated fatty acids were negatively associated with Proteobacteria (r= -0.43, p<0.05), while Lactobacillus genus was associated with monounsaturated fatty acids (r= -0.23, p=0.04). These findings reveal that the milk microbiota and lipid composition exhibit differences based on geographical locations in addition to the differences observed due to the mode of delivery.
topic Fatty Acids
Geography
microbiome
delivery
human milk
url http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01619/full
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