Detection of cytogenomic abnormalities by OncoScan microarray assay for products of conception from formalin-fixed paraffin-embedded and fresh fetal tissues

Detection of cytogenomic abnormalities by OncoScan microarray assay for products of conception from formalin-fixed paraffin-embedded and fresh fetal tissues

Abstract Background The OncoScan microarray assay (OMA) using highly multiplexed molecular inversion probes for single nucleotide polymorphism (SNP) loci enabled the detection of cytogenomic abnormalities of chromosomal imbalances and pathogenic copy number variants (pCNV). The small size of molecul...

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Bibliographic Details
Main Authors: Jiadi Wen, Brittany Grommisch, Autumn DiAdamo, Hongyan Chai, Sok Meng Evelyn Ng, Pei Hui, Allen Bale, Winifred Mak, Guilin Wang, Peining Li
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Cytogenetics
Subjects:
Products of conception (POC)
OncoScan microarray assay (OMA)
Formalin-fixed paraffin-embedded (FFPE) tissue
Aneuploidy
Polyploidy
Pathogenic copy number variant (pCNV)
Online Access:https://doi.org/10.1186/s13039-021-00542-5

Internet

https://doi.org/10.1186/s13039-021-00542-5

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