Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis

Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis

Pseudomonas aeruginosa is an opportunistic multidrug-resistant pathogen, able to grow in biofilms. It causes life-threatening complications in diseases characterized by the up-regulation of type I interferon (IFN) signaling, such as cancer or viral infections. Since type I IFNs regulate multiple fun...

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Bibliographic Details
Main Authors: Ekaterina Pylaeva, Sharareh Bordbari, Ilona Spyra, Anna Sophie Decker, Susanne Häussler, Vadim Vybornov, Stephan Lang, Jadwiga Jablonska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Pseudomonas aeruginosa
neutrophils
IFN-β
IFNAR
innate immunity
bacterial infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02190/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02190/full

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