Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide

Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide

Prothymosin α (proTα) and its C-terminal decapeptide proTα(100−109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreact...

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Bibliographic Details
Main Authors: Anastasios I. Birmpilis, Chrysoula-Evangelia Karachaliou, Pinelopi Samara, Kyriaki Ioannou, Platon Selemenakis, Ioannis V. Kostopoulos, Nadia Kavrochorianou, Hubert Kalbacher, Evangelia Livaniou, Sylva Haralambous, Athanasios Kotsinas, Farzin Farzaneh, Ioannis P. Trougakos, Wolfgang Voelter, Meletios-Athanasios Dimopoulos, Aristotelis Bamias, Ourania Tsitsilonis
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
adjuvant
antitumor peptide vaccine
biologic response modifier
danger-associated molecular pattern—damp
immunoreactive decapeptide
in vivo melanoma model
proinflammatory cytokine
prothymosin α
th1-type cytokine
Online Access:https://www.mdpi.com/2072-6694/11/11/1764

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https://www.mdpi.com/2072-6694/11/11/1764

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