Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties
N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+ and mechanism of memantine, an NMDAR antagonist.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02927-4 |