Hypoxia upregulates PGI-synthase and increases PGI2 release in human vascular cells exposed to inflammatory stimuli

Hypoxia upregulates PGI-synthase and increases PGI2 release in human vascular cells exposed to inflammatory stimuli

Hypoxia affects vascular function and cell metabolism, survival, growth, and motility; these processes are partially regulated by prostanoids. We analyzed the effect of hypoxia and inflammation on key enzymes involved in prostanoid biosynthesis in human vascular cells. In human vascular smooth muscl...

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Bibliographic Details
Main Authors: Mercedes Camacho, Cristina Rodríguez, Anna Guadall, Sonia Alcolea, Mar Orriols, José-Román Escudero, José Martínez-González, Luis Vila
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Journal of Lipid Research
Subjects:
cyclooxygenase-pathway
prostaglandin I-synthase
prostacyclin-synthase
prostacyclin
smooth muscle cells
endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752040906X

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http://www.sciencedirect.com/science/article/pii/S002222752040906X

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