Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

Abstract Background Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms,...

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Bibliographic Details
Main Authors: Gregory M. Jacobson, Logan J. Voss, Anica Klockars, Steve Bird, Ivo Dimitrov, William A. Denny, Pawel K. Olszewski, James W. Sleigh, Martyn G. Harvey
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Genomics
Subjects:
Ketamine
Analgesia
Transcriptome
Glutamate
Potassium channels
Nociception
Online Access:http://link.springer.com/article/10.1186/s12864-019-5649-6

Internet

http://link.springer.com/article/10.1186/s12864-019-5649-6

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