Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
Abstract Background Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms,...
Main Authors: | Gregory M. Jacobson, Logan J. Voss, Anica Klockars, Steve Bird, Ivo Dimitrov, William A. Denny, Pawel K. Olszewski, James W. Sleigh, Martyn G. Harvey |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-04-01
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Series: | BMC Genomics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12864-019-5649-6 |
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