Antibodies against glycolipids enhance antifungal activity of macrophages and reduce fungal burden after infection with Paracoccidioides brasiliensis

Antibodies against glycolipids enhance antifungal activity of macrophages and reduce fungal burden after infection with Paracoccidioides brasiliensis

Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected animals. Antibodies to GSL were active in...

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Bibliographic Details
Main Authors: Renata Amelia eBueno, Luciana eTomaz, Julian Esteban eMuñoz, Cassia eSilva, Joshua D Nosanchuk, Marcia Ribeiro Pinto, Luiz R Travassos, Carlos Pelleschi Taborda
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Microbiology
Subjects:
Glycosphingolipids
Paracoccidioidomycosis
Paracoccidioides brasiliensis
polyclonal antibodies
nitric oxide.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00074/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00074/full

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