Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

ObjectivesIn March 2020, the World Health Organization declared that an infectious respiratory disease caused by a new severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2, causing coronavirus disease 2019 (COVID-19)] became a pandemic. In our study, we have analyzed a large publicly availabl...

Full description

Bibliographic Details
Main Authors: Anton E. Shikov, Yury A. Barbitoff, Andrey S. Glotov, Maria M. Danilova, Ziravard N. Tonyan, Yulia A. Nasykhova, Anastasia A. Mikhailova, Olesya N. Bespalova, Roman S. Kalinin, Azizahon M. Mirzorustamova, Igor Yu Kogan, Vladislav S. Baranov, Alexander N. Chernov, Dragana M. Pavlovich, Sergey V. Azarenko, Mikhail A. Fedyakov, Victoria V. Tsay, Yuri A. Eismont, Olga V. Romanova, Dmitry N. Hobotnikov, Dmitry A. Vologzhanin, Sergei V. Mosenko, Tatiana A. Ponomareva, Yana A. Talts, Anna U. Anisenkova, Dmitrii G. Lisovets, Andrey M. Sarana, Stanislav P. Urazov, Sergey G. Scherbak, Oleg S. Glotov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Genetics
Subjects:
COVID-19
ACE2
mutations
eQTL
gnomAD
whole-exome sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.551220/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.551220/full

Similar Items