The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

Abstract All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mecha...

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Bibliographic Details
Main Authors: Nathalie Grandin, Bruno Pereira, Camille Cohen, Pauline Billard, Caroline Dehais, Catherine Carpentier, Ahmed Idbaih, Franck Bielle, François Ducray, Dominique Figarella-Branger, Jean-Yves Delattre, Marc Sanson, Patrick Lomonte, Delphine Poncet, Pierre Verrelle, Michel Charbonneau, POLA network
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Anaplastic astrocytoma
Secondary glioblastoma
Alternative lengthening of telomeres
IDH1/2 mutations
ATRX loss of expression
Online Access:http://link.springer.com/article/10.1186/s40478-019-0833-0

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http://link.springer.com/article/10.1186/s40478-019-0833-0

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