The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation

The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation

Oligodendrocyte and myelin deficits have been reported in mental/psychiatric diseases. The p21-activated kinase 3 (PAK3), a serine/threonine kinase, whose activity is stimulated by the binding of active Rac and Cdc42 GTPases is affected in these pathologies. Indeed, many mutations of Pak3 gene have...

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Bibliographic Details
Main Authors: Majistor Raj Luxman Maglorius Renkilaraj, Lucas Baudouin, Claire M. Wells, Mohamed Doulazmi, Rosine Wehrlé, Vidjeacoumary Cannaya, Corinne Bachelin, Jean-Vianney Barnier, Zhengping Jia, Brahim Nait Oumesmar, Isabelle Dusart, Lamia Bouslama-Oueghlani
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Neurobiology of Disease
Subjects:
PAK3
Differentiation
Oligodendrocyte
OPC
Intellectual disability
Myelin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302856

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http://www.sciencedirect.com/science/article/pii/S0969996116302856

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