Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423

Visualizing Mitochondrial FoF1-ATP Synthase as the Target of the Immunomodulatory Drug Bz-423

Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immunomodulatory compound Bz-423 is such a drug that binds to subunit OSCP of the mitochondrial FoF1-ATP synthase an...

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Bibliographic Details
Main Authors: Ilka Starke, Gary D. Glick, Michael Börsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
FoF1-ATP synthase
mitochondria
Bz-423
immunomodulator
drug target
Förster resonance energy transfer FRET
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00803/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00803/full

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