Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule. By direct carbonylation modification of the Pro222 residue in the actuator (A) domain of pig Na/K‐ATPase α1 subunit, reactive oxyg...

Full description

Bibliographic Details
Main Authors: Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu
Format: Article
Language:English
Published: Wiley 2016-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Na/K‐ATPase
protein carbonylation
protein trafficking
reactive oxygen species
signaling
sodium transport
Online Access:https://doi.org/10.1161/JAHA.116.003675

Internet

https://doi.org/10.1161/JAHA.116.003675

Similar Items