A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.

A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival. Nevertheless, one-third of CD patients develop chronic chagasic cardiomyopathy (CCC) associated with parasite persistence and immunological u...

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Bibliographic Details
Main Authors: Isabela Resende Pereira, Glaucia Vilar-Pereira, Virgínia Marques, Andrea Alice da Silva, Bráulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Maurício Martins Rodrigues, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4305326?pdf=render

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http://europepmc.org/articles/PMC4305326?pdf=render

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