Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell populations during fatal infection.

Bibliographic Details
Main Authors: Zhongfang Wang, Lingyan Zhu, Thi H. O. Nguyen, Yanmin Wan, Sneha Sant, Sergio M. Quiñones-Parra, Jeremy Chase Crawford, Auda A. Eltahla, Simone Rizzetto, Rowena A. Bull, Chenli Qiu, Marios Koutsakos, E. Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, James M. McCaw, Nicole L. La Gruta, Stephen J. Turner, Allen C. Cheng, Fabio Luciani, Xiaoyan Zhang, Peter C. Doherty, Paul G. Thomas, Jianqing Xu, Katherine Kedzierska
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03243-7

Internet

https://doi.org/10.1038/s41467-018-03243-7

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