Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.

Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.

In bronchopulmonary dysplasia (BPD), alveolar septae are thickened with collagen and α-smooth muscle actin, transforming growth factor (TGF)-β-positive myofibroblasts. Periostin, a secreted extracellular matrix protein, is involved in TGF-β-mediated fibrosis and myofibroblast differentiation. We hyp...

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Bibliographic Details
Main Authors: Paul D Bozyk, J Kelley Bentley, Antonia P Popova, Anuli C Anyanwu, Marisa D Linn, Adam M Goldsmith, Gloria S Pryhuber, Bethany B Moore, Marc B Hershenson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281961?pdf=render

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http://europepmc.org/articles/PMC3281961?pdf=render

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