Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

Abstract Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites including the substantia nigra pars compacta (SNc), which is related to phenotypic d...

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Bibliographic Details
Main Authors: Yukari Suda, Naoko Kuzumaki, Takefumi Sone, Michiko Narita, Kenichi Tanaka, Yusuke Hamada, Chizuru Iwasawa, Masahiro Shibasaki, Aya Maekawa, Miri Matsuo, Wado Akamatsu, Nobutaka Hattori, Hideyuki Okano, Minoru Narita
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Brain
Subjects:
Parkinson’s disease
Ghrelin
GHSR
iPS
Dopamine neuron
Online Access:http://link.springer.com/article/10.1186/s13041-018-0349-8

Internet

http://link.springer.com/article/10.1186/s13041-018-0349-8

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