Dietary cholesterol increases paraoxonase 1 enzyme activity
HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to rep...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2012-11-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520412623 |
id |
doaj-035a84a8aa654da4b77a15603f51e4f4 |
---|---|
record_format |
Article |
spelling |
doaj-035a84a8aa654da4b77a15603f51e4f42021-04-28T06:04:34ZengElsevierJournal of Lipid Research0022-22752012-11-01531124502458Dietary cholesterol increases paraoxonase 1 enzyme activityDaniel S. Kim0Amber A. Burt1Jane E. Ranchalis2Rebecca J. Richter3Julieann K. Marshall4Karen S. Nakayama5Ella R. Jarvik6Jason F. Eintracht7Elisabeth A. Rosenthal8Clement E. Furlong9Gail P. Jarvik10Departments of Medicine and University of Washington School of Medicine, Seattle, WA; Departments of Medicine and Genome Sciences, University of Washington School of Medicine, Seattle, WA; andDepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartment of General Medicine, Virginia Mason Medical Center, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WADepartments of Medicine and University of Washington School of Medicine, Seattle, WA; Departments of Medicine and Genome Sciences, University of Washington School of Medicine, Seattle, WA; andTo whom correspondence should be addressed; Departments of Medicine and University of Washington School of Medicine, Seattle, WA; Departments of Medicine and Genome Sciences, University of Washington School of Medicine, Seattle, WA; andHDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these findings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol (P < 2.0 × 10−16), alcohol (P = 8.51 × 10−8), vitamin C (P = 7.97 × 10−5), iron (P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C. Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease.http://www.sciencedirect.com/science/article/pii/S0022227520412623cholesterol/dietarydietdietary lipidsfolateLDL/oxidation/antioxidantsnutrition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel S. Kim Amber A. Burt Jane E. Ranchalis Rebecca J. Richter Julieann K. Marshall Karen S. Nakayama Ella R. Jarvik Jason F. Eintracht Elisabeth A. Rosenthal Clement E. Furlong Gail P. Jarvik |
spellingShingle |
Daniel S. Kim Amber A. Burt Jane E. Ranchalis Rebecca J. Richter Julieann K. Marshall Karen S. Nakayama Ella R. Jarvik Jason F. Eintracht Elisabeth A. Rosenthal Clement E. Furlong Gail P. Jarvik Dietary cholesterol increases paraoxonase 1 enzyme activity Journal of Lipid Research cholesterol/dietary diet dietary lipids folate LDL/oxidation/antioxidants nutrition |
author_facet |
Daniel S. Kim Amber A. Burt Jane E. Ranchalis Rebecca J. Richter Julieann K. Marshall Karen S. Nakayama Ella R. Jarvik Jason F. Eintracht Elisabeth A. Rosenthal Clement E. Furlong Gail P. Jarvik |
author_sort |
Daniel S. Kim |
title |
Dietary cholesterol increases paraoxonase 1 enzyme activity |
title_short |
Dietary cholesterol increases paraoxonase 1 enzyme activity |
title_full |
Dietary cholesterol increases paraoxonase 1 enzyme activity |
title_fullStr |
Dietary cholesterol increases paraoxonase 1 enzyme activity |
title_full_unstemmed |
Dietary cholesterol increases paraoxonase 1 enzyme activity |
title_sort |
dietary cholesterol increases paraoxonase 1 enzyme activity |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2012-11-01 |
description |
HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these findings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol (P < 2.0 × 10−16), alcohol (P = 8.51 × 10−8), vitamin C (P = 7.97 × 10−5), iron (P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C. Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease. |
topic |
cholesterol/dietary diet dietary lipids folate LDL/oxidation/antioxidants nutrition |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520412623 |
work_keys_str_mv |
AT danielskim dietarycholesterolincreasesparaoxonase1enzymeactivity AT amberaburt dietarycholesterolincreasesparaoxonase1enzymeactivity AT janeeranchalis dietarycholesterolincreasesparaoxonase1enzymeactivity AT rebeccajrichter dietarycholesterolincreasesparaoxonase1enzymeactivity AT julieannkmarshall dietarycholesterolincreasesparaoxonase1enzymeactivity AT karensnakayama dietarycholesterolincreasesparaoxonase1enzymeactivity AT ellarjarvik dietarycholesterolincreasesparaoxonase1enzymeactivity AT jasonfeintracht dietarycholesterolincreasesparaoxonase1enzymeactivity AT elisabetharosenthal dietarycholesterolincreasesparaoxonase1enzymeactivity AT clementefurlong dietarycholesterolincreasesparaoxonase1enzymeactivity AT gailpjarvik dietarycholesterolincreasesparaoxonase1enzymeactivity |
_version_ |
1721504238168702976 |