Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging.

Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging.

BACKGROUND:Local drug delivery systems that adjust the release of immunosuppressive drug in response to the nature and intensity of inflammation represent a promising approach to reduce systemic immunosuppression and its side effects in allotransplantation. Here we aimed to demonstrate that release...

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Bibliographic Details
Main Authors: Dzhuliya Dzhonova, Radu Olariu, Jonathan Leckenby, Ashish Dhayani, Praveen Kumar Vemula, Jean-Christophe Prost, Yara Banz, Adriano Taddeo, Robert Rieben
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6117083?pdf=render

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http://europepmc.org/articles/PMC6117083?pdf=render

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