Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest

Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest

The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of physiological glutamate signaling, but its role in pathological glutamate signaling (excitotoxicity) remains less clear, with indications for both neuro-toxic and neuro-protective functions. Here, the role of CaMKII in i...

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Bibliographic Details
Main Authors: Guiying Deng, James E. Orfila, Robert M. Dietz, Myriam Moreno-Garcia, Krista M. Rodgers, Steve J. Coultrap, Nidia Quillinan, Richard J. Traystman, K. Ulrich Bayer, Paco S. Herson
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
CaMKII
ischemia
cardiac arrest
tatCN19o
neuroprotection
LTP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300293

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http://www.sciencedirect.com/science/article/pii/S2211124717300293

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