Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

The alkaloid drug berberine (BBR) was recently described to decrease plasma cholesterol and triglycerides (TGs) in hypercholesterolemic patients by increasing expression of the hepatic low density lipoprotein receptor (LDLR). Using HepG2 human hepatoma cells, we found that BBR inhibits cholesterol a...

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Bibliographic Details
Main Authors: Jean-Marie Brusq, Nicolas Ancellin, Pascal Grondin, Raphaelle Guillard, Sandrine Martin, Yannick Saintillan, Marc Issandou
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein cholesterol
PD98059
5-aminoimidazole-4-carboxamide 1-β-ribofuranoside
fatty acid oxidation
phosphorylation of acetyl-coenzyme A carboxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332272

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http://www.sciencedirect.com/science/article/pii/S0022227520332272

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