Statistical correction of the Winner's Curse explains replication variability in quantitative trait genome-wide association studies.
Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5536394?pdf=render |