Serum proBDNF Is Associated With Changes in the Ketone Body β-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults

Serum proBDNF Is Associated With Changes in the Ketone Body β-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults

Background: β-hydroxybutyrate (BHB) can upregulate brain-derived neurotrophic factor (BDNF) in mice, but little is known about the associations between BHB and BDNF in humans. The primary aim here was to investigate whether ketosis (i.e., raised BHB levels), induced by a ketogenic supplement, influe...

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Bibliographic Details
Main Authors: Jakob Norgren, Makrina Daniilidou, Ingemar Kåreholt, Shireen Sindi, Ulrika Akenine, Karin Nordin, Staffan Rosenborg, Tiia Ngandu, Miia Kivipelto, Anna Sandebring-Matton
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
ketosis
brain-derived neurotrophic factor
proBDNF
signaling metabolites
repeatability
aged humans
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.716594/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.716594/full

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