Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

Although previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, and senescence does not completely abrogate its tumor suppression function, it is unclear how the remaining activities of p53 are regulated. Here, we have identified an acetylation site at lysine K98 in mouse...

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Bibliographic Details
Main Authors: Shang-Jui Wang, Dawei Li, Yang Ou, Le Jiang, Yue Chen, Yingming Zhao, Wei Gu
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631244X