Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications

Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis. Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in preclinical studies and is now moving from phase I/IIa to larger phase II studies aiming to demonstrate efficacy. However, hur...

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Bibliographic Details
Main Authors: Leila Amini, Jenny Greig, Michael Schmueck-Henneresse, Hans-Dieter Volk, Séverine Bézie, Petra Reinke, Carole Guillonneau, Dimitrios L. Wagner, Ignacio Anegon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
immune tolerance
transplantation
autoimmunity
genome editing
CAR
cell therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.611638/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.611638/full

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