Follicular Helper T (TFH) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients

Follicular Helper T (TFH) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients

Identifying signaling pathways that induce B cell response can aid functional cure strategies for chronic hepatitis B infection (CHB). TLR8 activation with ssRNA was shown to enhance follicular helper T cell (TFH) function leading to improved B cell responses in vitro. We investigated whether this m...

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Bibliographic Details
Main Authors: Natarajan Ayithan, Lydia Tang, Susanna K. Tan, Diana Chen, Jeffrey J. Wallin, Simon P. Fletcher, Shyam Kottilil, Bhawna Poonia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor 8
chronic hepatitis B
selgantolimod (SLGN)
follicular helper T cell
B cell
HBsAg-specific B cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.735913/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.735913/full

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