Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein

Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein

In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-syn...

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Bibliographic Details
Main Authors: Hazel L. Roberts, David R. Brown
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Biomolecules
Subjects:
α-synuclein
neurodegeneration
Parkinson’s disease
aggregation
toxic oligomers
amyloid fibrils
Online Access:http://www.mdpi.com/2218-273X/5/2/282

Internet

http://www.mdpi.com/2218-273X/5/2/282

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