Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and GPR109B that signal through G(i)-mediated inhibi...

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Bibliographic Details
Main Authors: Yira Bermudez, Claudia A Benavente, Ralph G Meyer, W Russell Coyle, Myron K Jacobson, Elaine L Jacobson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3105069?pdf=render

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http://europepmc.org/articles/PMC3105069?pdf=render

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