A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.

The human blood brain barrier (BBB) is a selective barrier formed by human brain endothelial cells (hBECs), which is important to ensure adequate neuronal function and protect the central nervous system (CNS) from disease. The development of human in vitro BBB models is thus of utmost importance for...

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Bibliographic Details
Main Authors: Romeo Cecchelli, Sezin Aday, Emmanuel Sevin, Catarina Almeida, Maxime Culot, Lucie Dehouck, Caroline Coisne, Britta Engelhardt, Marie-Pierre Dehouck, Lino Ferreira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24936790/?tool=EBI