GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.

GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.

Transcription factors act in concert to induce lineage commitment towards Th1, Th2, or T regulatory (Treg) cells, and their counter-regulatory mechanisms were shown to be critical for polarization between Th1 and Th2 phenotypes. FOXP3 is an essential transcription factor for natural, thymus-derived...

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Bibliographic Details
Main Authors: Pierre-Yves Mantel, Harmjan Kuipers, Onur Boyman, Claudio Rhyner, Nadia Ouaked, Beate Rückert, Christian Karagiannidis, Bart N Lambrecht, Rudolf W Hendriks, Reto Crameri, Cezmi A Akdis, Kurt Blaser, Carsten B Schmidt-Weber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2222968?pdf=render

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http://europepmc.org/articles/PMC2222968?pdf=render

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