Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer

Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer

Doxorubicin (DOX) is limited to use in clinical practice because of poor targeting, serious side effects and multidrug resistance (MDR). Vitamin E and its derivatives are currently considered as hydrophobic material that can reverse tumor MDR by suppressing the action of p-glycoprotein (p-gp). There...

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Bibliographic Details
Main Authors: Jing Mao, Lipeng Qiu, Lu Ge, Juan Zhou, Qian Ji, Yang Yang, Miaomiao Long, Danhui Wang, Liping Teng, Jinghua Chen
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Reduction-sensitive micelle
Heparosan polysaccharide
Vitamin E succinate
Doxorubicin
Tumor multidrug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313019

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http://www.sciencedirect.com/science/article/pii/S0753332220313019

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