Indirect detection of an epitope-specific response to HIV-1 gp120 immunization in human subjects.

A specific response of human serum neutralizing antibodies (nAb) to a conformational epitope as a result of vaccination of human subjects with the surface envelope glycoprotein (gp120) of HIV-1 has not previously been documented. Here, we used computational analysis to assess the epitope-specific re...

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Bibliographic Details
Main Authors: Evgeny Shmelkov, Arthur Nadas, James Swetnam, Susan Zolla-Pazner, Timothy Cardozo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3208624?pdf=render