Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

Abstract Background Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catalyze H3K4me3 and H3K36me3 and determine hotspot pos...

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Bibliographic Details
Main Authors: Ondrej Mihola, Vladimir Landa, Florencia Pratto, Kevin Brick, Tatyana Kobets, Fitore Kusari, Srdjan Gasic, Fatima Smagulova, Corinne Grey, Petr Flachs, Vaclav Gergelits, Karel Tresnak, Jan Silhavy, Petr Mlejnek, R. Daniel Camerini-Otero, Michal Pravenec, Galina V. Petukhova, Zdenek Trachtulec
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Biology
Subjects:
Rattus norvegicus
Meiotic recombination
PRDM9
Fertility
Online Access:https://doi.org/10.1186/s12915-021-01017-0

Internet

https://doi.org/10.1186/s12915-021-01017-0

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