BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia

Background/Purpose: The molecular pathophysiology of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains poorly understood. The Wnt signaling pathway and downstream targets, such as bone morphogenetic proteins (BMP) 4 and other factors such as late gestation lung protein 1 (LGL1), are...

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Bibliographic Details
Main Authors: Heather eEmmerton-Coughlin, Kathryn eMartin, Jacky eChiu, Lin eZhao, Leslie eScott, Timothy eRegnault, Andreana eButter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Surgery
Subjects:
Sheep
Wnt
Congenital Diaphragmatic Hernia
pulmonary hypoplasia
CDH
BMP4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fsurg.2014.00044/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fsurg.2014.00044/full

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