Anti-tumor effects of metformin in animal models of hepatocellular carcinoma: a systematic review and meta-analysis.

Several studies have reported that metformin can reduce the risk of hepatocellular carcinoma (HCC) in diabetes patients. However, the direct anti-HCC effects of metformin have hardly been studied in patients, but have been extensively investigated in animal models of HCC. We therefore performed a sy...

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Bibliographic Details
Main Authors: Juan Li, Pratika Y Hernanda, Wichor M Bramer, Maikel P Peppelenbosch, Judith van Luijk, Qiuwei Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4451077?pdf=render