Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline chloride (ChCl)/glycerol (1:2 mol/mol) and ChCl/ure...

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Bibliographic Details
Main Authors: Paola Vitale, Luciana Cicco, Ilaria Cellamare, Filippo M. Perna, Antonio Salomone, Vito Capriati
Format: Article
Language:English
Published: Beilstein-Institut 2020-08-01
Series:Beilstein Journal of Organic Chemistry
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Online Access:https://doi.org/10.3762/bjoc.16.158